And it just keeps getting cheaper…

Yesterday I mentioned how the price keeps dropping on genome re-sequencing, and already today I spot yet another post (on CLC Bio’s “Next Generation Sequencing” blog) on the very topic. Now VisiGen will start selling genome re-sequencing for $1000 — what I would consider the price at which you will start using re-sequencing rather than SNP typing — at the end of 2009.

Will we see the first re-sequencing association mapping studies in 2010?

Joining the DNA Network

Today I received an email from Hsien-Hsien Lei from Eye on DNA, inviting me to join the DNA Network (read a description of this network here). So now I have.

The DNA Headlines

I wasn’t even aware that this existed, but I am happy to learn about it. There is lots of interesting blogs there to follow (and I am a bit addicted to blog reading).

I am just a bit nervous if I have anything much to contribute to all this, but hey, if you don’t like my blog just stop reading it, right?

Dirt cheap whole genome re-sequencing

When writing grant applications I’ve been saying that we could expect whole genome re-sequencing in association mapping studies to be cost effective within the decade. I’m beginning to think that a decade is rather pessimistic.

The cost of re-sequencing is now down to $100,000.

Sure, that is about a factor of 100 more than just getting the SNPs covering your genome and probably tagging most interesting genetic factors we know about, but I would no longer be surprised if the cost would drop to $1000 for re-sequencing within a year, and $1000 was cheap enough for chip based whole genome association mapping studies, so it will be cheap enough for re-sequencing studies.

You can find more on the dropping cost of re-sequencing on Eye on DNA: Whole Genome Sequencing Costs Continue to Drop.

I’d better get cracking on developing analysis methods that can then actually analyse such data…

Next generation sequencing blog

CLC Bio has started a new blog on “next generation sequencing” — whatever they mean by that. Check it out here and see the announcement here.

CLC Bio is a bioinformatics company here in Aarhus and I have several old friends working there. The software they develop looks very nice, but I haven’t really used it myself. It doesn’t really match the problems I work with myself. What’s cooler, though, is that they also develop custom hardware for computationally intensive bioinformatics tasks: The Cube and The Cell.

I’m not really sure what’s supposed to go on their new blog, but since I’m a sucker for science blogs I’ll probably subscribe to it for a while and find out.

The expanding world of small RNAs

The regulatory machinery built from small RNA genes is a fairly recent discovery and a very exciting one. There’s a short overview paper about it in Nature:

Molecular biology: The expanding world of small RNAs Nature 451, 414 (2008). doi:10.1038/451414a Helge Großhans & Witold Filipowicz